Palmitoylation at a conserved cysteine residue facilitates gasdermin D-mediated pyroptosis and cytokine release.

Gasdermin D (GSDMD)-mediated pyroptotic cell death drives inflammatory cytokine release and downstream immune responses upon inflammasome activation, which play important roles in host defense and inflammatory disorders. Upon activation by proteases, the GSDMD N-terminal domain (NTD) undergoes oligomerization and membrane translocation in the presence of lipids to assemble pores. Despite intensive studies, the molecular events underlying the transition of GSDMD from an autoinhibited soluble form to an oligomeric pore form inserted into the membrane remain incompletely understood.

Intractable Seizures in Children With Type 1 Diabetes: Implications of the Ketogenic Diet.

Introduction: The ketogenic diet is prescribed for seizures in some children with epilepsy. Children with type 1 diabetes are at risk for diabetic ketoacidosis caused by ketosis due to decreased insulin effect. Currently there are no clinical guidelines regarding the safety and efficacy of the ketogenic diet in patients with concurrent epilepsy and type 1 diabetes.

The significance of adrenal metastases from lung carcinoma.

Aim: The aim of our study was to correlate spread of the lung cancer into the adrenal glands with the progression of the primary disease.

Methods: We diagnosed and confirmed adrenal metastases in 50 patients with non-small cell lung cancer (NSCLC). We correlated the site of the primary lung carcinoma with the site of the adrenal metastasis, and the adrenal metastasis pattern, ipsi-, contra-, and bilateral adrenal metastases, with the operability and number of other sites of metastatic disease.