Single-cell recording and stimulation with a 16k micro-nail electrode array integrated on a 0.18 μm CMOS chip.

To cope with the growing needs in research towards the understanding of cellular function and network dynamics, advanced micro-electrode arrays (MEAs) based on integrated complementary metal oxide semiconductor (CMOS) circuits have been increasingly reported. Although such arrays contain a large number of sensors for recording and/or stimulation, the size of the electrodes on these chips are often larger than a typical mammalian cell. Therefore, true single-cell recording and stimulation remains challenging.

Micro-sized syringes for single-cell fluidic access integrated on a micro-electrode array CMOS chip.

Very-large scale integration and micro-machining have enabled the development of novel platforms for advanced and automated examination of cells and tissues in vitro. In this paper, we present a CMOS chip designed in a commercial 0.18 μm technology with integrated micro-syringes combined with micro-nail shaped electrodes and readout electronics.

Temperature determination of resonantly excited plasmonic branched gold nanoparticles by X-ray absorption spectroscopy.

The fields of bioscience and nanomedicine demand precise thermometry for nanoparticle heat characterization down to the nanoscale regime. Since current methods often use indirect and less accurate techniques to determine the nanoparticle temperature, there is a pressing need for a direct and reliable element-specific method. In-situ extended X-ray absorption fine structure (EXAFS) spectroscopy is used to determine the thermo-optical properties of plasmonic branched gold nanoparticles upon resonant laser illumination.

PreOp endoscopy simulator: from bronchoscopy to ureteroscopy.

The high cost of virtual reality simulators has posed a major obstacle to the widespread adoption of simulators for medical training. HT Medical broke through this cost barrier by developing the PreOp Flexible Bronchoscopy simulator, a realistic training simulation system that integrates force feedback, multimedia, and 3D graphics on a PC. We are currently extending the PreOp platform so that it can simulate other endoscopic procedures.

Predictability of a three-dimensional planning system for oral implant surgery.

Objectives: To compare 2D CT alone with 2D + 3D reconstruction for pre-operative planning of implant placement.

Methods: Spiral CT scans of 33 consecutive patients were used for both reformatted 2D and 3D computer-assisted planning. The number, site and size of implants and the occurrence of anatomical complications during planning and implant placement were statistically compared using the percentage agreement and the Kendall's correlation coefficients (tau).