Publications by authors named "K Venkatachalam"
Macrophages are highly variable immune cells that are important in controlling inflammation and maintaining tissue balance. The ability to polarize into two major types-M1, promoting inflammation, and M2, resolving inflammation and contributing to tissue repair-determines their specific roles in health and disease. M2 macrophages are particularly important for reducing inflammation and promoting tissue regeneration, but their function is shaped mainly by surrounding cells.
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- PAPS is synthesized in two steps: first, ATP sulfurylase converts ATP into APS, then APS-kinase phosphorylates APS to produce PAPS.
- Mutations in the hPAPSS isoform1, particularly in histidine residues, disrupt the function of ATP sulfurylase without affecting APS-kinase.
- The N-K mutant exhibited improved catalytic efficiency for ATP and sulfate, indicating how specific residues can enhance enzyme activity and the importance of inter-domain interactions in the overall structure and function of hPAPSS1.
Article Synopsis
- The study highlights the urgent need for improved treatments for chronic myeloid leukemia (CML), given the high incidence and mortality rates among men and women.
- It investigates the potential enhanced effects of combining inecalcitol with existing therapies imatinib and dasatinib on various cancer cell lines.
- Results showed that while some cell lines were resistant, AR-230 and LAMA-84-s exhibited significant cell-killing effects, suggesting that the effectiveness of combined treatments varies depending on the specific cell type.
This comprehensive review discusses the crucial role of copper in human health and disease as an essential trace mineral. It emphasizes the significance of copper while addressing potential risks from imbalances in copper levels, be it excessive or inadequate. The review outlines various challenges in copper research, including toxicity concerns, data limitations, metabolic complexities, genetic influences, nutrient interactions, and resource constraints.
View Article and Find Full Text PDFCaregivers' perceptions of feeding practices and diet diversity among children aged 12-59 months in a rural district of South India: an analytical cross-sectional study.
BMJ Open
October 2024
Objective: The primary objective of this study was to assess caregivers' perceptions of feeding practices (breastfeeding and complementary feeding) and diet diversity among children aged 12-59 months in a rural district of South India. The secondary objective was to identify potential predictors of these perceptions and diet diversity.
Design: An analytical cross-sectional study was performed from March 2023 to May 2023.