Publications by authors named "K Vedhagiri"
Leptospirosis is an important global public health problem. Favourable environmental factors are influencing the survival of leptospires in soil, which is an important link in the transmission cycle. The present study was designed to understand the correlation between various soil nutrients and presence of Leptospira in soil samples of different regions of Andaman and Nicobar Islands.
View Article and Find Full Text PDFSeroprevalence of leptospirosis among a healthy population of the South Andaman Island was assessed through random sampling. Previous studies have high seroprevalences of up to 55% in general population and 65% in agricultural labourers. The study subjects (1,181 in total, 781 rural and 400 urban) were interviewed and tested for antibodies against Leptospira.
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- Subminimal inhibitory concentrations (sub-MICs) of antibiotics, specifically doxycycline and tetracycline, were found to promote biofilm formation in certain leptospiral strains.
- This is the first study to report such an effect of sub-MIC antibiotics on Leptospira, suggesting that even low antibiotic levels can trigger biofilm development.
- Further research is necessary to explore the underlying mechanisms and clinical implications of this phenomenon, particularly its role in hindering effective treatment of chronic leptospirosis.
Leptospira is the causative agent of leptospirosis, which is an emerging zoonotic disease. Recent studies on Leptospira have demonstrated biofilm formation on abiotic surfaces. The protein expressed in the biofilm was investigated by using SDS-PAGE and immunoblotting in combination with MALDI-TOF mass spectrometry.
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