Publications by authors named "K Varagur"
Objective: The objective of this study was to evaluate whether volumetric measurements on early cranial ultrasound (CUS) in high-grade germinal matrix hemorrhage-intraventricular hemorrhage (GMH-IVH) are associated with hydrocephalus and neurodevelopmental metrics.
Methods: A retrospective case series analysis of infants with high-grade GMH-IVH admitted to the St. Louis Children's Hospital neonatal intensive care unit between 2007 and 2015 who underwent neurodevelopmental testing using the Bayley Scales of Infant and Toddler Development, 3rd Edition (Bayley-III) at 2 years of corrected age was performed.
Article Synopsis
- The study investigates how prenatal surgery affects the development and treatment of hydrocephalus in children with myelomeningocele (MMC), noting that a significant percentage still develop hydrocephalus despite surgery.
- Researchers analyzed clinical, imaging, and demographic data from 58 patients with MMC treated either before or after birth to identify predictors for hydrocephalus treatment.
- Key findings indicate that prenatal ventricle size, frontal-occipital horn ratio at birth, and early rates of head circumference change are strong predictors for the need and timing of hydrocephalus treatment in both prenatal and postnatal cohorts.
Objective: The need for permanent CSF diversion is lower in patients who have undergone prenatal surgery for myelomeningocele (MMC) than in those who have undergone postnatal closure. Differences in brain development and head growth between treatment groups are not known, particularly for those who do not require surgical treatment for hydrocephalus. The objective of this study was to determine differences in head growth and to generate MMC-specific head circumference (HC) growth curves for patients who underwent either prenatal or postnatal surgery.
View Article and Find Full Text PDFMRI analysis of neurodevelopmental anatomy in myelomeningocele: prenatal vs postnatal repair.
Ultrasound Obstet Gynecol
September 2024
Objective: Compared with postnatal repair, prenatal myelomeningocele (MMC) repair is associated with improved motor function and decreased need for cerebrospinal fluid (CSF) diversion. It is unknown how prenatal surgery alters neuroanatomical structures identifiable on magnetic resonance imaging (MRI). The purpose of this study was to use MRI to compare neurodevelopmental anatomy in patients undergoing fetal MMC repair compared with those undergoing postnatal repair.
View Article and Find Full Text PDFObjective: To examine whether neighborhood disadvantage impacts length of follow-up, interventions, and outcomes for patients with cleft palate.
Design: Retrospective cohort.
Setting: Cleft Palate Craniofacial Institute Database at St.