Publications by authors named "K Vanova"
Mitochondrial respiratory complex II is altered in renal carcinoma.
Biochim Biophys Acta Mol Basis Dis
January 2025
Article Synopsis
- * Using samples from 78 RCC patients, the study compared tumor tissue to adjacent healthy tissue, finding low mitochondrial DNA and protein levels in ccRCC tumors while observing changes in mitochondrial content and function linked to tumor grade.
- * The results indicate that as ccRCC severity increases, CII function declines, which could help doctors categorize patients by prognosis and explore targeted therapies.
Integrated genomic analysis reveals actionable targets in pediatric spinal cord low-grade gliomas.
Acta Neuropathol Commun
September 2022
Gliomas are the most common central nervous tumors in children and adolescents. However, spinal cord low-grade gliomas (sLGGs) are rare, with scarce information on tumor genomics and epigenomics. To define the molecular landscape of sLGGs, we integrated clinical data, histology, and multi-level genetic and epigenetic analyses on a consecutive cohort of 26 pediatric patients.
View Article and Find Full Text PDFHistone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, suggesting a developmental context permissive to their effects. Here we show that 50% of G34R/V tumors (n = 95) bear activating PDGFRA mutations that display strong selection pressure at recurrence.
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