Publications by authors named "K Vandenbroeck"
Article Synopsis
- Young scientists were asked to suggest a change in scientific policy or culture.
- The goal of the prompt was to find solutions that could lower rates of scientific misconduct and unethical practices.
- Responses are aimed at promoting integrity and accountability in scientific research.
Atherosclerosis is the main risk factor for cardiovascular disease (CVD), which is the leading cause of mortality worldwide. Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways. The resultant atheroma plaque, along with these processes, results in cardiovascular complications.
View Article and Find Full Text PDFBoosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple-Cell 2D Atherosclerosis Model.
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April 2022
Cardiovascular disease, the leading cause of mortality worldwide, is primarily caused by atherosclerosis, which is characterized by lipid and inflammatory cell accumulation in blood vessels and carotid intima thickening. Although disease management has improved significantly, new therapeutic strategies focused on accelerating atherosclerosis regression must be developed. Atherosclerosis models mimicking in vivo-like conditions provide essential information for research and new advances toward clinical application.
View Article and Find Full Text PDFIntronic single-nucleotide polymorphisms (SNPs) in the gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis by genome-wide association studies (GWAS). The risk alleles have been linked to higher expression levels of and the neighboring (gp130) gene in CD4 T lymphocytes of healthy controls. The biological function of ANKRD55, its role in the immune system, and cellular sources of expression other than lymphocytes remain uncharacterized.
View Article and Find Full Text PDFArticle Synopsis
- - Multiple sclerosis (MS) is an intricate disease that damages the central nervous system, and understanding its genetic basis is crucial for finding potential therapies after the advances in genome-wide association studies (GWAS).
- - Researchers identified a specific genetic variant, rs7740107, linked to MS risk at the L3MBTL3 locus by studying a group of MS patients and healthy controls, discovering it influences the expression of related genes.
- - The variant rs7740107 leads to the production of a novel short transcript that generates truncated proteins, potentially disrupting crucial interactions with other proteins that regulate the Notch signaling pathway, further influencing MS pathology.