Publications by authors named "K Van Weelden"
Article Synopsis
- - Congenital diaphragmatic hernia (CDH) is a birth defect caused by improper development of the diaphragm, often linked to genetic factors that either contribute to or cause the condition, sometimes occurring alongside other anomalies.
- - Genetic evaluation has evolved from karyotyping to next-generation sequencing (NGS), allowing for the identification of more potential pathogenic variants, but complications arise in interpreting these findings and their clinical relevance.
- - The variability in CDH presentation and its genetic basis complicates diagnosis and treatment, highlighting the need for thorough patient monitoring and large patient cohorts for better understanding and management of the disorder.
SUM-159PT cells: a novel estrogen independent human breast cancer model system.
Breast Cancer Res Treat
December 1999
Breast cancer remains one of the most common malignant diseases in women in North America and Western Europe, yet therapies for the more aggressive estrogen independent tumors are limited and few model systems are available for the study of this type of breast cancer. In these studies, we characterized a novel estrogen independent breast cancer cell line, SUM-159PT. SUM-159PT cells are epithelial in origin, demonstrated by expression of cytokeratin 18.
View Article and Find Full Text PDF1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D2 inhibits breast cancer cell growth both in vivo and in vitro. In addition to its anti-proliferative effects, 1,25(OH)2D3 induces morphological and biochemical markers of apoptosis in MCF-7 cells. In the studies reported here, we compared the effects of 1,25(OH)2D3 and EB1089, a low calcemic vitamin D analog, on cell cycle kinetics and apoptosis in MCF-7 cells.
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