Publications by authors named "K Van Calsteren"
Child outcomes after prenatal exposure to platinum and taxane-based chemotherapy: an unplanned interim analysis of the international network on cancer, infertility, and pregnancy study.
Indra A Van Assche Kristel Van Calsteren Evangeline A Huis In 't Veld Mathilde van Gerwen Laura Heylen
EClinicalMedicine
December 2024
Background: Platina and taxanes are frequently used chemotherapeutic agents to treat cancer, also when diagnosed during pregnancy. This report presents an interim analysis of the largest series of children prenatally exposed to platinum and/or taxane agents and aims to determine their physical health and neurocognitive outcomes.
Methods: As part of a multicentre, prospective cohort study (ClinicalTrials.
Article Synopsis
- A descriptive study aimed to analyze pregnant women with cancer who died during pregnancy, delivery, or within the first year postpartum, using data from the International Network on Cancer, Infertility and Pregnancy (INCIP) registry.
- Out of 2,359 registered women, 131 (5.6%) experienced maternal mortality, with lung, gastro-oesophageal cancer, and acute leukaemia showing the highest mortality rates.
- The findings indicated that maternal mortality was linked to fewer live births, more elective caesarean sections, and earlier deliveries, resulting in an increased incidence of preterm births.
Purpose: Postpartum haemorrhage (PPH) remains a leading cause of maternal death despite current medical management. Surgical interventions are still needed for refractory bleeding. Interventional radiology (IR) can be a successful intermediary that avoids the need for hysterectomy.
View Article and Find Full Text PDF