Fastening in Rock Mass-Structural Design of Shallow Embedded Anchors in Inhomogeneous Substrate.

Unlike traditional base materials such as concrete or masonry, there are no guidelines for rock as a base material for post-installed anchors. The varying rock properties (e.g.

Informed Consent in COVID-19-Research: An Ethical Analysis of Clinical Studies Performed during the Pandemic.

Health crises such as the current COVID-19 pandemic pose challenges to the conduct of clinical studies. Aspects of research ethics, such as obtaining informed consent (IC), can be complicated. We are concerned with whether or not the proper IC procedures were followed in the context of clinical studies at Ulm University in the years 2020 to 2022.

Influence of Measurement Uncertainty in the Determination of Selected Rock Parameters-A Realistic Approach.

To determine and compare the measurement uncertainty of different geological-geotechnical testing methods, numerous test locations were selected in a hard rock quarry. Measurements were carried out along two vertical measurement lines perpendicular to the mining levels of an existing exploration. Along these lines, the rock quality basically varies due to weathering (decreasing influence with increasing distance from the original ground surface), but also due to the influence of the geological-tectonic conditions on site.

Voluntariness or legal obligation? An ethical analysis of two instruments for fairer global access to COVID-19 vaccines.

Introduction: There is currently no binding, internationally accepted and successful approach to ensure global equitable access to healthcare during a pandemic. The aim of this ethical analysis is to bring into the discussion a legally regulated vaccine allocation as a possible strategy for equitable global access to vaccines. We focus our analysis on COVAX (COVID-19 Vaccines Global Access) and an existing EU regulation that, after adjustment, could promote global vaccine allocation.

A three-photon head-mounted microscope for imaging all layers of visual cortex in freely moving mice.

Advances in head-mounted microscopes have enabled imaging of neuronal activity using genetic tools in freely moving mice but these microscopes are restricted to recording in minimally lit arenas and imaging upper cortical layers. Here we built a 2-g, three-photon excitation-based microscope, containing a z-drive that enabled access to all cortical layers while mice freely behaved in a fully lit environment. The microscope had on-board photon detectors, robust to environmental light, and the arena lighting was timed to the end of each line-scan, enabling functional imaging of activity from cortical layer 4 and layer 6 neurons expressing jGCaMP7f in mice roaming a fully lit or dark arena.