Developing Novel Experimental Models of m-TORopathic Epilepsy and Related Neuropathologies: Translational Insights from Zebrafish.

The mammalian target of rapamycin (mTOR) is an important molecular regulator of cell growth and proliferation. Brain mTOR activity plays a crucial role in synaptic plasticity, cell development, migration and proliferation, as well as memory storage, protein synthesis, autophagy, ion channel expression and axonal regeneration. Aberrant mTOR signaling causes a diverse group of neurological disorders, termed 'mTORopathies'.

[Use of dabigatran etexilate for treatment of deep vein thrombosis and pulmonary artery thromboembolism].

The authors present herein their experience in oral administration of dabigatran etexilate for treatment of lower-limb deep vein thrombosis and pulmonary thromboembolism in patients with thrombophilia, as well as assessment of its efficacy and safety. The study included a total of nineteen 20-to-79-year-old patients (11 men and 8 women) with venous thromboembolic complications. An inclusion criterion was the presence of lower-limb deep vein thrombosis documented in the B-mode in ultrasonography alone or in a combination with pulmonary thromboembolism confirmed by angiopulmonography end echocardiography.

Melting of graphene: from two to one dimension.

The high temperature behaviour of graphene is studied by atomistic simulations based on an accurate interatomic potential for carbon. We find that clustering of Stone-Wales defects and formation of octagons are the first steps in the process of melting which proceeds via the formation of carbon chains. The molten state forms a three-dimensional network of entangled chains rather than a simple liquid.

Finite temperature lattice properties of graphene beyond the quasiharmonic approximation.

The thermal and mechanical stability of graphene is important for many potential applications in nanotechnology. We calculate the temperature dependence of the lattice parameter, elastic properties, and heat capacity by means of atomistic Monte Carlo simulations that allow us to go beyond the quasiharmonic approximation. We predict an unusual, nonmonotonic, behavior of the lattice parameter with a minimum at T approximately 900 K and of the shear modulus with a maximum at the same temperature.