Screening for hemoglobin disorders and investigating their hematological and demographic profile among patients attending a tertiary-care hospital in southern India-a descriptive study.

Background: Hemoglobinopathies and thalassemias are widely prevalent autosomal inherited recessive disorders of the structure and synthesis of hemoglobin, respectively. Given the regional heterogeneity of these disorders, this study was undertaken to elucidate the patterns and prevalence of these disorders from this region.

Methods: This was a tertiary-care hospital-based study in southern India over 4 years.

Single-molecule detection of a terrylenediimide-based near-infrared emitter.

Environment-sensitive fluorescent agents with near-infrared (NIR) emission are in great demand owing to their applications in biomedical and quantum technologies. We report a novel NIR absorbing ( = 734 nm) and emitting ( = 814 nm) terrylenediimide (TDI) based donor-acceptor chromophore (TDI-TPA), exhibiting polarity-sensitive single-photon emission. By virtue of the charge transfer (CT) character, ensemble level measurements revealed solvatochromism and NIR emission ( = 26.

Electron diffraction and solid-state NMR reveal the structure and exciton coupling in a eumelanin precursor.

Eumelanin, a versatile biomaterial found throughout the animal kingdom, performs essential functions like photoprotection and radical scavenging. The diverse properties of eumelanin are attributed to its elusive and heterogenous structure with DHI (5,6-dihydroxyindole) and DHICA (5,6-dihydroxyindole-2-carboxylic acid) precursors as the main constituents. Despite DHICA being recognized as the key eumelanin precursor, its crystal structure and functional role in the assembled state remain unknown.

Guest-Mediated Modulation of Photophysical Pathways in a Coronene Bisimide Cyclophane.

The properties and functions of chromophores utilized by nature are strongly affected by the environment formed by the protein structure in the cells surrounding them. This concept is transferred here to host-guest complexes with the encapsulated guests acting as an environmental stimulus. A new cyclophane host based on coronene bisimide is presented that can encapsulate a wide variety of planar guest molecules with binding constants up to (4.