Design, development and in vitro-in vivo study of tramadol-paracetamol inlay tablets.

The objective of this work is to formulate, optimize and evaluate in-lay tablets of tramadol-paracetamol. This study investigated the effect of hydrophobic, plastic and hydrophilic types of polymers and their content level on release profile of a highly water-soluble drug tramadol hydrochloride. A 3(2) full factorial design was employed for the optimization of the sustained release (SR) formula of tramadol hydrochloride using ethyl cellulose, eudragit and carbopol.

Aflatoxin induced hepatocarcinogenesis in ducks.

To assess the carcinogenic response of duck hepatic tissue, an experimental study was undertaken. Pure aflatoxin B1, was administered to twelve white pekin ducks of two to three months of age at a dose rate of 0.04165 mg/kg body weight every third day for six months.

A bovine herpesvirus (BHV-4) as passenger virus in ethmoidal tumours in Indian cattle.

A herpesvirus was isolated from tumours of the ethmoidal mucosa in two of three head of cattle in the State of Kerala, India. The virus designated M40 was cytopathic for a variety of cultured bovine and porcine cells and it did not kill suckling mice or chicken embryos. Sera from tumour-bearing cattle and goats reacted with the M40 virus.

Distribution and ultrastructure of mast cells in the duck.

The distribution and ultrastructure of mast cells in the duck were studied. Carnoy's fluid was found to be the best fixative, and Padawer's method was found to be useful in demonstrating the metachromasia. Mast cells were seen in many of the organs and were most numerous in the proventriculus.

Evaluation of the cell mediated immune response in pigs using 2,4-dinitrochlorobenzene.

An experiment was carried out to measure the cell mediated immune response in pigs by sensitising the animals with 2,4-dinitrochlorobenzene (DNCB). The pigs could be sensitised with one application of DNCB. The appropriate site for application and the sensitising and challenge dose were standardised.