Publications by authors named "K V Titova"
Article Synopsis
- - The vaccinia virus has been historically used as a smallpox vaccine, but due to its reactogenicity, WHO recommended discontinuation after smallpox was eradicated, leading to a rise in orthopoxvirus infections, notably the 2022 monkeypox epidemic.
- - Researchers developed modified VACV strains, LAD and LADA, with specific genetic alterations to reduce reactogenicity while enhancing the immune response compared to the original L strain.
- - Both LAD and LADA strains demonstrated superior cellular immune responses and higher levels of VACV-specific IgG in vaccinated mice, indicating their potential as safer and more effective vaccines against orthopoxvirus infections.
Article Synopsis
- The 2022 monkeypox epidemic highlighted the need for smallpox vaccinations, particularly for high-risk groups.
- Modern vaccination methods include intramuscular and skin scarification (s.s.), but intradermal (i.d.) delivery might provide better immune responses.
- A study comparing s.s. and i.d. routes in mice showed that i.d. injection led to higher antibody production and stronger immunity against cowpox, making it a more effective vaccination method.
Article Synopsis
- The study investigates a 94-kDa protein from vaccinia virus (VACV), a truncated version of the cowpox virus's A-type inclusion protein, which is important for the virus's immunogenicity but does not contribute to neutralization.
- Researchers created a recombinant VACV strain (LIVPΔati) by deleting a gene related to this protein and tested its effects on pathogenicity and immunogenicity in mice.
- Results showed that LIVPΔati caused less mortality in infected mice and induced a stronger antibody response compared to the parent virus, while both strains elicited similar cell-mediated immunity.
Article Synopsis
- The monkeypox virus outbreak outside Africa in 2022 has highlighted the urgent need for immunization, which could be achieved using a first-generation smallpox vaccine licensed in Russia.
- Current guidelines recommend transepidermal inoculation (skin scarification), but this method has reliability issues, prompting the exploration of intradermal (i.d.) injection as an alternative vaccination technique.
- A study compared these two methods in mice, finding no significant difference in antibody responses, but a stronger T-cell immune response with i.d. injection; both methods provided protection against cowpox, while i.d. immunization resulted in a 50% survival rate against a lethal strain of ectromelia virus.
Sulfur and chlorine compounds in water bodies of the Pymvashor subarctic hydrothermal system.
Environ Sci Pollut Res Int
February 2023
The results of the study of the behavior of redox-dependent sulfur and chlorine compounds in sediments of water bodies of the Pymvashor natural boundary (PNB) located in the Bolshezemelskaya Tundra (the Polar Cis-Ural Region, Nenets Autonomous Okrug, Russian Federation) are presented. Currently, the Pymvashor is the only known location in Continental Europe where hydrothermal springs function in the polar territories. Data on the quantitative characteristics of the geochemical parameters of bacterial sulfate reduction (reduced sulfur compounds, reactive iron forms, and organic matter) in the sediments of all studied Pymvashor water bodies have been obtained.
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