A Small-molecule Antagonist Radiotracer for Positron Emission Tomography Imaging of the Mu Opioid Receptor.

The opioid crisis is a catastrophic health emergency catalyzed by the misuse of opioids that target and activate the mu opioid receptor. Traditional radioligands used to study the mu opioid receptor are often tightly regulated owing to their abuse and respiratory depression potential. In the present study, we sought to design and characterize a library of 24 non-agonist ligands for the mu opioid receptor.

Selective electrodialysis for nutrient recovery and pharmaceutical removal from liquid digestate: Pilot-scale investigation and potential fertilizer production.

The present research employs a pilot-scale selective electrodialysis system to treat liquid digestate, fractionating nutrient ions and exploring fertilizer creation via ammonia stripping and phosphorus precipitation, while studying pharmaceutical transport behavior and examining membrane fouling. The influence of diverse potentials was studied in simulated and real digestate, with 30 V application proven more efficient overall. Applying consecutive runs resulted in products that were 7.

Correction: Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice multichannel image segmentation.

Correction for 'Multiplexed molecular imaging with surface enhanced resonance Raman scattering nanoprobes reveals immunotherapy response in mice multichannel image segmentation' by Chrysafis Andreou , , 2022, , 1540-1552, https://doi.org/10.1039/d2nh00331g.

Valorization of Anaerobic-Fermentation Liquid Digestates-Membrane-Based Process Development.

Complete valorization of various wastes and effluents, with significant organic content, remains a great challenge in the pursuit of a circular economy. The approach based on anaerobic fermentation, leading to valuable biogas production, has been broadly accepted and employed as an attractive processing scheme. However, despite notable research efforts, complete valorization of the digestates (involving recovery of nutrients/by-products and full recycling/reuse of treated water) requires additional work for sustainable process development.