"Silver dust"--a tool to study growth interrelationships between bone, periosteum and muscle.

A cylinder of gelatin containing silver spongy granules was placed in and lay within the masseter muscle, the periosteum, and the mandible, and terminated in the medial pterygoid muscle of young (3 month-old) growing miniature pigs. On the basis of an animal sacrificed one week after placement of the cylinder, it was found that the suspending gelatin was removed by cellular activity. Nine months later the remaining animals were sacrificed.

Functional morphology of the pressure- and the volume-hypertrophied rat heart.

We studied hearts in which hypertrophy was caused by both pressure and volume overload. Pressure hypertrophy was induced by an aortic constriction; volume hypertrophy was induced by an iron-copper deficiency (anemia). The ventricular weight was increased by 34% in the pressure-hypertrophied hearts at the end of 6 weeks.

Fiber bundle direction in the mammalian heart. An extension of the "nested shells" model.

The orientation of the muscle fiber bundles within the mammalian left ventricle was examined in a variety of mammals. The hearts were arrested in situ in animals with an intact thorax by means of an isotonic K+ solution perfused via the aorta and coronaries. The hearts were then fixed by formalin perfusion through the same vessels and the hearts embedded in gelatin.