Publications by authors named "K V Ermakova"
Article Synopsis
- Upregulation of TNF-α is linked to autoimmune diseases, prompting the development of fluorescent antibodies for personalized therapy.
- Two types of recombinant fluorescent proteins targeting TNF were created: BTN-Kat, which binds TNF without neutralizing it, and ITN-Kat, which binds and neutralizes human TNF.
- BTN-Kat is useful for whole-body imaging, while ITN-Kat shows promise as a theranostic agent in treating autoimmune diseases.
The efficiency of photodynamic therapy with photosensitizer Tiosens (Russia) was evaluated in mono- and combined therapy of rats with malignant gliomas (glioblastoma 101/8, oligodendroglioma 14-4-9, and C6 glioma). The efficiency of photodynamic monotherapy was not high: the animals died from brain edema developing in tumor tissue and in the adjacent normal cerebral tissue. Pathomorphological studies of tumor tissue detected necrosis and apoptosis, destruction of vessels with hemorrhages, and vascular thrombosis.
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