Effects of one-week lithium treatment on skilled performance, information processing, and mood in healthy volunteers.

In a double-blind study, effects of lithium on skilled performance, information processing, and mood were studied in 12 healthy men. Lithium was administered for 1 week and the average, steady state, serum lithium concentration on the morning of testing was 0.8 mEq/liter.

Effects of chronic zimelidine and ethanol on psychomotor performance.

Twelve healthy men between 22 and 27 years of age participated in an experiment on interactions between zimelidine and ethanol. Zimelidine, 200 mg/24 hours, was administered for 10 days and ethanol, 0.5 and 1.

Effects of antidepressants on skilled performance.

Effects of amitriptyline 50 mg, desipramine 100 mg, and zimelidine 200 mg alone and in combination with ethanol 0.8 g/kg were investigated in healthy, male volunteers. Amitriptyline increased body sway and impaired tracking as well as information processing.