Publications by authors named "K V Danichkina"
Article Synopsis
- Accumulation of beta-amyloid peptides (Aβ) and their modifications, particularly phosphorylated serine-8 (pSer8-Aβ), are key factors in the progression of Alzheimer's disease (AD), influencing neuronal degradation and cytotoxicity.* -
- The study found that pSer8-Aβ levels in the brains of 5xFAD mice steadily increase from 3 months to 14-17 months, paralleling the general accumulation of Aβ peptides, and that pSer8-Aβ constitutes up to 1-10% of total Aβ in the cerebrospinal fluid of AD patients.* -
- Mass spectrometry confirmed the possibility of specific Aβ phosphorylation in brain tissues, suggesting
The study of the molecular mechanisms of the pathogenesis of Alzheimer's disease (AD) is extremely important for identifying potential therapeutic targets as well as early markers. In this regard, the study of the role of post-translational modifications (PTMs) of β-amyloid (Aβ) peptides is of particular relevance. Serine-8 phosphorylated forms (pSer8-Aβ) have been shown to have an increased aggregation capacity and may reflect the severity of amyloidosis.
View Article and Find Full Text PDF