Publications by authors named "K Urbanek"
Background: Human cardiac organoids closely replicate the architecture and function of the human heart, offering a potential accurate platform for studying cellular and molecular features of aging cardiomyopathy. Senolytics have shown potential in addressing age-related pathologies but their potential to reverse aging-related human cardiomyopathy remains largely unexplored.
Methods: We employed human iPSC-derived cardiac organoids (hCOs/hCardioids) to model doxorubicin(DOXO)-induced cardiomyopathy in an aged context.
Ewing sarcoma is a rare malignant neoplasm that primarily affects bone in children. Extraskeletal location is less common, while intradural extramedullary Ewing sarcoma (IEES) in adults is a casuistic phenomenon. Due to its rarity, a standardized treatment strategy for IEES has not been established.
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- Traumatic brain injury (TBI) and hemorrhage significantly contribute to trauma-related fatalities, especially in patients with polytrauma, leading researchers to explore better diagnostic and prognostic methods.
- The study utilized blood samples from a cohort to assess the predictive ability of glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) levels in patients experiencing hemorrhagic shock, with or without TBI, through classification tree analysis.
- Results indicated that GFAP levels, particularly greater than 286 pg/ml at patient arrival, effectively predicted TBI presence and associated outcomes, whereas UCH-L1 did not show significant predictive value in the studied scenarios.
Article Synopsis
- Heart failure (HF) is a significant global health issue, especially for the aging population; this study investigates the drug sacubitril/valsartan's effects on aging-related HF with preserved ejection fraction (HFpEF) in rats.
- After 12 weeks of treatment, both sacubitril/valsartan and valsartan showed improvements in cardiac hypertrophy, evidenced by reduced heart muscle thickness, but neither treatment effectively reduced myocardial fibrosis or corrected diastolic dysfunction.
- The study indicates that while the treatments positively impacted heart muscle size and activated cardioprotective signaling pathways, challenges like inflammation and oxidative stress remained unaddressed, leaving diastolic dysfunction and fibrosis in aging hearts.
Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors, anti-diabetic drugs in heart failure and cognitive impairment: potential mechanisms of the protective effects.
Front Pharmacol
June 2024
Article Synopsis
- Heart failure and cognitive impairment are significant public health issues, especially as the global population ages, with strong links to age and multiple health issues.
- Type 2 diabetes increases risks for both heart and brain health, promoting conditions like heart failure and cognitive decline due to its metabolic complications.
- New anti-diabetic medications, such as GLP-1R agonists and SGLT2 inhibitors, show promise in reducing the risk of cardiovascular and neurological issues beyond just controlling blood sugar, but further research is needed to fully understand their mechanisms.