Publications by authors named "K Uney"
Article Synopsis
- Danofloxacin, a fluoroquinolone antibiotic, is effective against bacterial infections in fish, but its pharmacokinetics vary based on fish size, impacting its medicinal effectiveness.!* -
- A study conducted on rainbow trout demonstrated that larger fish have higher plasma concentrations and overall drug efficacy of danofloxacin compared to smaller fish, with measurements taken after oral administration.!* -
- While larger fish show increased therapeutic efficacy, their higher drug concentrations in tissues raise concerns about potential residue and withdrawal time for safe consumption.!*
1. The objective of this research was to compare the pharmacokinetics and bioavailability of tolfenamic acid, analgesic, antipyretic and anti-inflammatory compound, after administration through different routes to Pekin ducks. The investigation was carried out over four time periods using a randomised cross-pharmacokinetic design.
View Article and Find Full Text PDFObjective: This study aimed to investigate the plasma and milk pharmacokinetics, as well as the withdrawal time (WT) from milk of tolfenamic acid (2 and 4 mg/kg) following intravenous (IV) administration to eight healthy lactating Akkaraman sheep.
Methods: The trial was conducted in two periods in accordance with a crossover pharmacokinetic design. The concentrations of tolfenamic acid in the plasma and milk were determined using high-pressure liquid chromatography and evaluated using non-compartmental analysis.
Article Synopsis
- The study aimed to examine how the pharmacokinetics of marbofloxacin varies with the age of calves after a single IV dose of 10 mg/kg.
- It involved Montofon calves of different ages (1, 2, and 4 months), measuring plasma concentrations and calculating pharmacokinetic parameters like half-life, volume of distribution, total clearance, and area under the curve (AUC) using HPLC.
- Findings indicated that as calves age, the elimination half-life and AUC decrease while total clearance increases, suggesting that the effectiveness of marbofloxacin may decline with age, calling for a reevaluation of the dosing strategy based on the bacteria's minimum inhibitory concentration (MIC) values.
Objective: The aim of this study was to determine the plasma pharmacokinetics of oxytetracycline (OTC) in rainbow trout () of different body sizes.
Methods: The research was carried out on three groups as small (30-50 g), medium (90-110 g) and large (185-215 g) body sizes at 8 ± 0.5 °C.