Structural and optical studies of fluoride ion binding using N-heteroaromatic ligands.

8-Hydroxyquinoline and imidazole, two important N-heteroaromatic systems, have a strong affinity towards various anions their acidic OH or NH protons. Three receptor ligands, 5-(1-benzo[]imidazol-2-yl)quinolin-8-ol (1), 5-(benzo[]thiazol-2-yl)quinolin-8-ol (2), and 4-(1-benzo[]imidazol-2-yl)benzene-1,3-diol (3), were synthesized, and their fluoride (F) ion binding properties were investigated. These ligands could selectively bind F ions, and their respective F complexes, namely, 1-TBAF, 2-TBAF, and 3-TBAF (TBAF = tetrabutylammonium fluoride), were characterized using single crystal X-ray analysis, NMR, UV-vis, Hirshfeld surface (HS) analysis and computational studies.

Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis.

The protozoan parasite Giardia intestinalis is one of only a few organisms lacking de novo synthesis of DNA building blocks (deoxyribonucleotides). Instead, the parasite relies exclusively on salvaging deoxyadenosine and other deoxyribonucleosides from its host environment. Here, we report that G.

Associations of Food Group Intakes with Serum Carbon Isotope Ratio Values in Youth: Results from 2 Prospective Pediatric Cohort Studies.

Background: The carbon isotope ratio (CIR) is a candidate biomarker for sugar-sweetened beverage (SSB) intake in the United States. However, research specific to youth, who differ in their physiology and dietary patterns compared with adults, is lacking.

Objectives: We evaluated longitudinal associations of SSB intakes across childhood/adolescence with serum CIR.

Associations between maternal microbiome, metabolome and incidence of low-birth weight in Guatemalan participants from the Women First Trial.

Background: Low birth weight (LBW; <2,500 g) affects approximately 15 to 20 percent of global births annually and is associated with suboptimal child development. Recent studies suggest a link between the maternal gut microbiome and poor obstetric and perinatal outcomes. The goal of this study was to examine relationships between maternal microbial taxa, fecal metabolites, and maternal anthropometry on incidence of LBW in resource-limited settings.