Publications by authors named "K Uchimura"
Spinal cord injury (SCI) results in damage to neural circuits that cause long-term locomotor and sensory disability. The objective of the present study is to evaluate whether a clinical drug, protamine, can be employed as a therapeutic agent for SCI. First, we examined the rescue effect of protamine on dystrophic endballs (DEs) cultured on a chondroitin sulfate (CS) gradient coating.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the effectiveness of cryobiopsy compared to conventional biopsy methods for diagnosing peripheral pulmonary lesions (PPLs) with ground-glass opacity (GGO), finding that cryobiopsy leads to significantly higher diagnostic yields.
- A total of 553 patients were analyzed, with a comparison between 250 cases who had cryobiopsy and 303 who had conventional biopsies, leading to a matched analysis of 232 pairs with enhanced results for the cryo group.
- While cryobiopsy showed a diagnostic yield of 88.8% versus 63.8% for conventional methods, it was associated with a higher incidence of bleeding complications, though no grade 4 bleeding was reported.
Examining worry and secondary stressors on grief severity using machine learning.
Anxiety Stress Coping
August 2024
Background & Objectives: Worry and loss-related secondary stressors appear to be important correlates of problematic grief responses. However, the relative importance of these variables in the context of established correlates of grief responding, ranging from indicators of identity disruption and demographic characteristics of the bereaved to characteristics of the loss of quality of the relationship with the deceased, is unknown. Modeling the relative associations of these factors can be problematic, given the high degree of collinearity between these variables.
View Article and Find Full Text PDFThe tumor suppressor TP53 gene, the most frequently mutated gene in human cancers, produces the product tumor protein p53, which plays an essential role in DNA damage. p53 protein mutations may contribute to tumorigenesis by loss of tumor suppressive functions and malignancy of cancer cells via gain-of-oncogenic functions. We previously reported that mutant p53 proteins form aggregates and that cytoplasmic p53 aggregates were associated with poor prognosis in human ovarian cancer.
View Article and Find Full Text PDFBackground: Mid-treatment cross-border migration of patients with TB increases the risk of treatment interruption.
Objective: To establish a cross-border referral process for patients with TB in Japan, and enhance their access to health facilities and treatment outcomes.
Design: This prospective cohort study describes and assesses the process of foreign-born patients with TB who returned to their home countries during treatment, focusing on their access to healthcare facilities and treatment outcomes.