Covalent Organic Framework as Selective Fluorescence Sensors for Cancer Inducing Volatile Organic Compounds.

Certain volatile organic compounds (VOCs), such as formaldehyde, acetone, and ethanol, are overexpressed in some terminal diseases like cancer, diabetes, Alzheimer's, etc. Therefore, high-precision detection and quantification of VOCs is imperative for early diagnosis of such detrimental diseases. Non-invasive and accurate fluorescence-based detection of such analytes has garnered widespread attention.

Synthesis of Indolo[2,3/3,2-]quinoline through Complementary PIDA/BF·OEt as Well as Pd(0)-Mediated Intramolecular Cyclization of Isomeric -((Aryl)--(phenylsulfonyl)indolyl)methylbenzenesulfonamides.

Herein, a straightforward facile synthesis of indolo[2,3-]quinoline analogues was reported from 2-arylamino(phenylsulfonyl)methylindoles involving PIDA/BF·OEt-mediated intramolecular dehydrogenative coupling (IDC) as a key step. Even though isomeric 3-arylamino(phenylsulfonyl)methylindoles, upon interaction with PIDA/BF·OEt, led to complications, synthesis of the indolo[3,2-]quinoline framework could be easily achieved from -(2-iodoaryl)--indolylmethylbenzenesulfonamide by employing a Pd(0)-mediated intramolecular cyclization reaction. Under identical conditions, synthesis of indolo[2,3-]quinolines was also accomplished from the respective -(2-iodoaryl)--indolylmethylbenzenesulfonamides.

The crystal structures and Hirshfeld surface analysis of three new bromo-substituted 3-methyl-1-(phenyl-sulfon-yl)-1-indole derivatives.

Three new 1-indole derivatives, namely, 2-(bromo-meth-yl)-3-methyl-1-(phenyl-sulfon-yl)-1-indole, CHBrNOS, (), 2-[()-2-(2-bromo-5-meth-oxy-phen-yl)ethen-yl]-3-methyl-1-(phenyl-sulfon-yl)-1-indole, CHBrNOS, (), and 2-[()-2-(2-bromo-phen-yl)ethen-yl]-3-methyl-1-(phenyl-sulfon-yl)-1-indole, CHBrNOS, (), exhibit nearly orthogonal orientations of their indole ring systems and sulfonyl-bound phenyl rings. Such conformations are favourable for inter-molecular bonding involving sets of slipped π-π inter-actions between the indole systems and mutual C-H⋯π hydrogen bonds, with the generation of two-dimensional monoperiodic patterns. The latter are found in all three structures, in the form of supra-molecular columns with every pair of successive mol-ecules related by inversion.

Synthesis of Cytotoxic Quino[4,3-]carbazole Frameworks through an Intramolecular Diels-Alder Reaction.

An intramolecular Diels-Alder reaction of positionally isomeric indole-2/3-phenylvinyl--alkynylated (-phenylsulfonyl)amines has been successfully exploited for the synthesis of quino[4,3-]carbazole and its analogues. This reaction proceeds through a [4 + 2] cycloaddition followed by elimination and deprotection of phenylsulfonyl units to afford the quinocarbazoles in moderate to good yields. The reaction features a broad substrate scope and remarkable functional group forbearance.