Publications by authors named "K Turteltaub"
Impact of phenanthrene co-administration on the toxicokinetics of benzo[a]pyrene in humans. UPLC-accelerator mass spectrometry following oral microdosing.
Chem Biol Interact
September 2023
Article Synopsis
- Current risk assessments for environmental carcinogens often rely on animal studies with doses much higher than what humans actually encounter, leading to uncertainties in evaluating risks.
- This study utilized accelerated mass spectrometry to analyze how a specific carcinogen, benzo[a]pyrene (BaP), behaves in the human body when taken alone or alongside another compound, phenanthrene (Phe), noting significant changes in absorption and distribution.
- The findings suggest that Phe interferes with the absorption of BaP, indicating that the presence of other chemicals in the environment can significantly influence how carcinogens affect human health, which hasn't been thoroughly studied before.
Article Synopsis
- The study investigates the effect of Brussels sprouts (BS) and 3,3'-diindolylmethane (DIM) on the metabolism of a known carcinogen, [C]-benzo[a]pyrene (BaP), using ultra-performance liquid chromatography-accelerator mass spectrometry (UPLC-AMS).
- Volunteers who consumed BS or DIM for a week had lower plasma levels of [C]-BaP and its metabolites after oral micro-dosing, with reductions indicating slower absorption and potentially enhanced clearance.
- This preliminary research suggests that dietary interventions can influence the toxicokinetics of carcinogens in humans, marking a significant step in understanding how diet may affect cancer risk.
Dibenzo[def,p]chrysene (DBC) is an environmental polycyclic aromatic hydrocarbon (PAH) that causes tumors in mice and has been classified as a probable human carcinogen by the International Agency for Research on Cancer. Animal toxicity studies often utilize higher doses than are found in relevant human exposures. Additionally, like many PAHs, DBC requires metabolic bioactivation to form the ultimate toxicant, and species differences in DBC and DBC metabolite metabolism have been observed.
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- * A study investigated the uptake, metabolism, and elimination of carbon-labeled BaP in human plasma using 25 to 250 ng doses over time, showcasing significant inter-individual variability in how BaP is processed in the body.
- * Results indicated that after oral dosing, only about 3-6% of BaP remained as the parent compound in plasma due to extensive metabolism, with non-compartmental modeling revealing a dose-dependent increase in volume distribution and a predominance of
FOLFOX is one of the most effective treatments for advanced colorectal cancer. However, cumulative oxaliplatin neurotoxicity often results in halting the therapy. Oxaliplatin functions predominantly via the formation of toxic covalent drug-DNA adducts.
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