Gene Expression in Breast Cancer Is Associated With Worse Prognosis, but Better Response to Chemotherapy and Immunotherapy.

Background: Vascular endothelial growth factor-A (VEGFA) is a key inducer of angiogenesis, responsible for generating new blood vessels in the tumor microenvironment (TME) and facilitating metastasis. Notably, Avastin, which targets VEGFA, failed to demonstrate any significant benefit in clinical trials for breast cancer (BC). This study aimed to investigate the clinical relevance of gene expression in BC.

Compact Disc-Derived Nanocarbon-Supported Catalysts with Extreme Catalytic Activity.

Advanced carbon-metal hybrid materials with controllable electronic and optical properties, as well as chemical reactivities, have attracted significant attention for emerging applications, including energy conversion and storage, catalysis and environmental protection. However, the commercialization of these materials is hampered by several vital problems, including energy-intensive synthesis and expensive chemicals, and inefficient control of their structures and properties. Herein, we report the simple and controllable engineering of nanocarbon-metal self-assembled silver nanocatalysts (SSNs) derived from polycarbonate (PC)-based optical discs using microplasmas under ambient conditions.

Effectiveness of amnion allograph injections in patients with degenerative musculoskeletal diseases: a systematic review and meta-analysis.

Objective: Amnion allograft injections have emerged as potential regenerative therapy for degenerative musculoskeletal diseases. In this study, we conducted a systematic review and meta-analysis to evaluate the effectiveness of amnion allograph injections in patients with degenerative musculoskeletal diseases.

Design: A search was conducted across the PubMed, Embase, Cochrane, and Web of Science databases to identify studies reporting on amnion allograft injections in patients with degenerative musculoskeletal diseases.

Improving Redox Activity of Colloidal Plasmonic-Magnetic Nanocrystals by Chemical State Modulation.

Controlling the redox ability is crucial for optimizing catalytic processes in clean energy, environmental protection, and CO reduction, as it directly influences the reaction efficiency and electron transfer rates, driving sustainable and effective outcomes. Here, we report the plasma-electrified synthesis of composition-controlled FeAu bimetallic nanoparticles, specifically engineered to enhance the redox catalytic performance through precise tuning of their chemical states. Utilizing atmospheric-pressure microplasmas, FeAu nanoparticles were synthesized under ambient conditions without the need for reducing agents or organic solvents, thereby providing a green and sustainable approach.