Publications by authors named "K Tsushima"
We report the case of a 76-year-old male patient with systemic sclerosis positive for anti-eukaryotic initiation factor 2B (eIF2B) antibodies. He presented to our hospital with dyspnea on exertion and, following a comprehensive physical examination, was diagnosed with interstitial lung disease associated with systemic sclerosis. Furthermore, systemic sclerosis was positive for the anti-eIF2B antibody.
View Article and Find Full Text PDFApolipoprotein A2-ATQ/AT (apoA2-ATQ/AT) is a new biomarker for diagnosing pancreatic cancer (PC). In this study, the value of blood carbohydrate antigen 19-9 (CA19-9) and apoA2-ATQ/AT levels in diagnosing stage 0 and IA PC was evaluated. During 2014-2021, 12 patients with stage 0 PC and 12 patients with IA PC (average age: 73.
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- * A total of 81 patients were included, with 63 in the chronic ILD group and 18 in the acute ILD group; several serum markers such as TAT, D-dimer, and SP-D were analyzed.
- * In AE-ILD, SP-D levels positively correlated with various coagulation markers, suggesting that these coagulation indicators may help in diagnosing AE-ILD alongside traditional alveolar damage markers.
Article Synopsis
- - The study focuses on drug-induced interstitial lung disease (DILD), aiming to identify specific biomarkers to enhance clinical management and improve drug development outcomes.
- - Researchers discovered that serum levels of kynurenine and quinolinic acid were significantly higher in acute DILD patients compared to other lung disease patients and healthy controls, suggesting these could serve as effective diagnostic markers.
- - The findings indicate a potential relationship between increased kynurenine levels and inflammation, with experiments showing that certain inflammatory conditions can activate the kynurenine pathway in macrophages, contributing to elevated biomarker levels in DILD.
Severe left ventricular failure can progress to right ventricular failure, necessitating alternatives to heart transplantation, such as total artificial heart (TAH) treatment. Conventional TAHs encounter challenges associated with miniaturization and hemocompatibility owing to their reliance on mechanical valves and bearings. A magnetically levitated TAH (IB-Heart) was developed, utilizing a magnetic bearing.
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