[Subcutaneous Injection of Efgartigimod, a New Therapeutic Agent for Generalized Myasthenia Gravis].

Patients with generalized myasthenia gravis (gMG) suffer from significant physical and social burdens. Although immunotherapies have been widely used for the treatment of gMG, some patients do not achieve or maintain remission. Recently, several molecular-targeting therapies of gMG, including the intravenous infusion of efgartigimod alfa (efgartigimod IV), a neonatal Fc receptor inhibitor, have been developed and are clinically used in Japan.

Preoperative loop length determination for mitral valve repair by 4-dimensional computed tomography.

Objective: In the loop technique for mitral valve repair, the loop bundles are usually created during cardiac arrest after chordal length measurements, which seems time-consuming and less reproducible. To address this issue, we determined the loop length preoperatively using 4-dimensional computed tomography.

Methods: The loop length was determined on the basis of the distance from the papillary muscle head to the free margin of nonprolapsing leaflet corresponding to the prolapsed leaflet, to which the loops would be secured.

Selenium nanoboosting of plant-beneficial microbiome.

In the dynamic theater of plant-microbe interactions, a new conductor has emerged: selenium nanoparticles. As unveiled by Sun et al. in this issue of Cell Host & Microbe, these microbially synthesized nanoparticles recruit plant growth-promoting microbes, orchestrating a synergy between plants and the rhizosphere microbiome.

Early Resolution of Abnormal Vascular Networks After Superficial Temporal Artery to Middle Cerebral Artery (STA-MCA) Bypass Surgery for Twig-Like Middle Cerebral Artery With Intracerebral Hemorrhage: A Case Report.

The twig-like middle cerebral artery (T-MCA) is a rare condition characterized by unilateral middle cerebral artery (MCA) occlusion and abnormal vascular networks, resembling Moyamoya Disease (MMD). While some reports mention bypass surgery for T-MCA, akin to MMD, there is no established treatment method. Previous reports highlight the efficacy of revascularization procedures in preventing recurrent strokes in T-MCA patients, but there is limited data on its usefulness for cases with intracerebral hemorrhagic onset.