Publications by authors named "K Tsubota"
Article Synopsis
- The study investigates the link between myopia (nearsightedness) and uveitis by comparing the axial lengths (AL) of eyes affected by uveitis to those of healthy controls.
- A total of 1052 eyes from uveitis patients and 738 control eyes were analyzed, revealing that the median AL in uveitis patients was significantly shorter than in controls, indicating a potential relationship.
- Specifically, the research found that shorter AL correlates with a higher risk of developing uveitis, with each millimeter decrease in AL increasing risk by 1.266 times.
Article Synopsis
- The retina is important for interpreting visual information and its study can aid in understanding myopia development.
- This research utilized a new method to identify and quantify proteins in mouse retinas, discovering over 6,263 unique protein groups related to myopia.
- A comprehensive spectral library of retinal proteins was created, which can be a valuable resource for future research on myopia and other retinal or neurological conditions.
Myopia is a global public health concern, with a higher prevalence in women than that in male. As the relationship between sex hormone and myopia remains unclear, we aimed to reveal the relationship between sex hormone and myopia by removing the ovaries of mice and measuring changes in ocular parameters related to myopia. Lens-induced myopia (LIM) surgeries were performed on 3-week-old male mice and age-matched female mice to evaluate the effects of sex on myopia development, which indicated a high degree of myopia and rapid progression of axial elongation in male mice.
View Article and Find Full Text PDFComprehensive microRNA analyses using vitreous humor of ocular sarcoidosis.
Graefes Arch Clin Exp Ophthalmol
September 2024
Purpose: MicroRNAs (miRNAs) are non-coding RNAs which have attracted attention as biomarkers in a variety of diseases. However, extensive unbiased analysis of miRNA in vitreous humor of sarcoidosis patients has not been reported. In the present study, we comprehensively analyzed the dysregulated miRNAs in ocular sarcoidosis to search for potential biomarkers.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to uncover unique protein markers associated with ocular graft-versus-host disease (GVHD) by analyzing corneal samples from GVHD model mice and control mice four weeks post-bone marrow transplantation.
- - Researchers conducted proteomic analysis and identified key protein pathways upregulated in GVHD, including necroptosis, MAPK, and neutrophil extracellular trap pathways, along with newly upregulated molecules involved in these processes.
- - The findings could provide insights into the mechanisms behind ocular GVHD and pave the way for developing new therapies targeting corneal issues in affected patients.