[Etiopathogenesis and type of congenital malformations observed in Kinshasa (Zaïre)].

The authors report on 115 malformed newborns, who are compared with 120 normal newborns from October 1985 up to September 1986 at the University Clinics of Kinshasa, Zaïre. There were 4,422 deliveries with 4,465 newborns, of whom 173 died during the perinatal period. The main results are: 1) the incidence of congenital defects is 2.

Chronic renal failure in tropical Africa.

The high occurrence of end-stage renal disease among black Americans is a well established feature. Black Africans are also more affected by chronic renal diseases. This lethal condition may constitute a great challenge for nephrologists in the tropics where financial resources to fund dialysis treatment are very scarce.

Intracellular sodium and the response to nitrendipine or atenolol in African blacks.

The relationship between the hypotensive effect of nitrendipine (N), 20 mg/day (n = 17), or atenolol (A), 100 mg/day (n = 17), and the erythrocyte sodium [( Na]i) and potassium [( K]i) concentrations was investigated in hypertensive African blacks during a randomized double-blind study. After 6 weeks, both treatments significantly reduced supine and standing blood pressures; however, the magnitude of the decrease in supine systolic (-22.0 +/- 2.

Calcium entry blockade or beta-blockade in long-term management of hypertension in blacks.

The long-term efficacy of nitrendipine and acebutolol was assessed during a 40-week double-blind randomized trial in 60 hypertensive blacks. Nitrendipine (mean dose 32 mg/day) and acebutolol (414 mg/day) were administered in monotherapy in increasing dosage and mefruside was added in patients not controlled by monotherapy. The recumbent and standing blood pressures were reduced (P less than 0.