Publications by authors named "K Toyama"
Retinopathy of prematurity (ROP) is primarily caused by the exposure of preterm infants with underdeveloped blood vessels to high oxygen concentrations. This damages the astrocytes that promote normal vascular development, leading to avascularity, pathological neovascularization, and retinal detachment, and even blindness as the disease progresses. In this study, the aim was to investigate the differences in the characteristics of astrocytes and blood vessels between wild-type (WT) and genetically modified mice overexpressing platelet-derived growth factor subunit A (PDGF-A) in the retina immediately after high oxygen exposure, a protocol in the oxygen-induced retinopathy (OIR) model of ROP.
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- Delivering agricultural advice effectively at scale presents challenges, but using technology, such as video content, can enhance learning and adoption among farmers if carefully implemented.* -
- A study in India tested videos on female farmers to promote System Rice Intensification practices alongside traditional methods, showing significant but varied positive effects, particularly for those with higher yields.* -
- Analysis revealed that additional supportive materials, such as information on labor costs and role models, further improved the effectiveness of the treatment, indicating a targeted approach can yield better outcomes.*
Aims: Direct oral anticoagulants (DOACs) are used to treat venous thromboembolism (VTE). However, their impact on thrombus regression and the clinical outcomes after 2-week post-therapy computed tomography (CT) monitoring remains unexplored. This study aimed to elucidate the characteristics of patients with VTE treated with individual DOACs, assess the incidence of clinical events, and evaluate their impact on pulmonary artery thrombus regression.
View Article and Find Full Text PDFRensch's Rule describes a pattern of interspecific allometry in which sexual size dimorphism (SSD) increases with size among closely related species (i.e., among a group of related species, the largest ones tend to show more male-biased SSD).
View Article and Find Full Text PDFObjective: The exact relationship between fibroblast growth factor 2 (FGF2) and choroidal neovascularization (CNV) remains unclear. In this study, using optical coherence tomography angiography (OCTA) and FGF2-tg mice which are transgenic mice with a rhodopsin promoter/FGF2 gene fusion, we aimed to investigate the dynamics of FGF2's role in angiogenesis over time.
Methods: We developed laser-induced CNV models of FGF2-tg and wild-type (WT) mice and then separated them into two groups using different laser photocoagulation (PC) conditions.