Patients undergoing staged bilateral knee arthroplasty are less aware of their kinematic aligned knee compared to their mechanical knee.

Objective: To compare knee joint awareness following kinematic alignment (KA) TKA in patients who had previously undergone mechanical alignment (MA) on their contralateral knee.

Methods: We performed a retrospective study of all consecutive patients who underwent staged bilateral TKA, the first using MA technique and the second utilizing the KA technique, without patient specific instrumentations. Primary outcome was assessed by the Forgotten Joint Score (FJS) with a minimum 1-year follow-up.

Glycosylation of Type I Collagen.

Fibrillar type I collagen is the most abundant structural protein in most tissues and organs. One of the unique and functionally important characteristics of collagen is sequential posttranslational modifications of lysine (Lys) residues. In the endoplasmic reticulum, hydroxylation of specific Lys occurs producing 5-hydroxylysine (Hyl).

Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.

Lower plasma levels of the oxysterol cholestenoic acid associate with increased mortality and organ failure in septic patients with acute respiratory distress syndrome (ARDS). Cholestenoic acid warrants further validation as a novel ARDS biomarker.

Cytochrome P450-derived epoxyeicosatrienoic acids and coronary artery disease in humans: a targeted metabolomics study.

Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) exhibit potent cardiovascular protective effects in preclinical models, and promoting the effects of EETs has emerged as a potential therapeutic strategy for coronary artery disease (CAD). The relationship between circulating EET levels and CAD extent in humans, however, remains unknown. A panel of free (unesterified) plasma eicosanoid metabolites was quantified in 162 patients referred for coronary angiography, and associations with extent of CAD [no apparent CAD (N = 39), nonobstructive CAD (N = 51), and obstructive CAD (N = 72)] were evaluated.