Physiological effects of alfaxalone anesthesia on rhesus monkeys during intravenous glucose tolerance testing.

Laboratory animal research with nonhuman primates (NHPs) requires anesthesia for most procedures to ensure safety and consistency in sample collection. However, anesthesia drugs can have adverse effects on the physiological measures of interest. Alfaxalone, most notably used in dogs and cats, offers rapid onset, short duration of action, and has a high safety margin.

Induction of immunity and inflammation by interleukin-12 family members.

The interleukin (IL)-12 family is composed of three heterodimeric cytokines, IL-12 (p40p35), IL-23 (p40p19), and IL-27 (EBI3p28), and of monomeric and homodimeric p40. This review focuses on the three heterodimeric members of the IL-12 family. The p40 and p40-like (EBI3) subunits have homology to the IL-6R, the other subunits (p35, p19, and p28) are homologous to each other and to members of the IL-6 superfamily.

Detection of p53 gene mutations in exhaled breath condensate of non-small cell lung cancer patients.

Early diagnosis of lung carcinoma is greatly desired. A potential source of early information regarding the process of cancerisation in the airways is exhaled breath condensate (EBC). The direct approach to detecting cancerisation is examining DNA from the area of chronic damage, i.

[Revision of the radium isodose atlas of Göttingen with a new calculation method].

The Radium Isodose Atlas of Göttingen was recalculated after having established a new computer program for the determination of dose distributions around intracavitary radium inserts. The program takes into consideration the complicated structure of the radium applicators type Buchler. The exactness of the program was checked by computing known radium sources and by detailed measures.

A simple function describing the absorption in platinum for dose-rate calculations around radium applicators.

The diminution of exposure rate from radium gamma radiation by filtration through platinum can be described very accurately by gamma 0/(1 + mu0d) for wall thickness d from 0.2 mm to 4.0 mm (gamma 0 = 6.