Publications by authors named "K Thueng-In"
Foot-and-mouth disease (FMD) is a highly infectious disease of cloven-hoofed animals with a significant economic impact. Early diagnosis and effective prevention and control could reduce the spread of the disease which could possibly minimize economic losses. Epitope characterization based on monoclonal antibodies provide essential information for developing diagnostic assays and vaccine designs.
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- RNA-dependent RNA polymerase (RdRp) is a promising target for antiviral therapies due to its critical role in RNA virus replication and absence of human equivalents.
- A newly developed cell-penetrating antibody, PEN-HuscFv34, effectively inhibits replication of various RNA viruses, indicating its potential as a broad-spectrum anti-RNA virus agent.
- The study introduces a streamlined production method combining Sortase self-cleavage and bacterial surface display to facilitate the large-scale generation of this super antibody, maintaining its antiviral efficacy.
Article Synopsis
- PRRSV is a highly impactful virus that causes significant economic losses in the pig industry, totaling around $664 million annually, and current vaccines are not very effective.
- The study focuses on developing porcine single-chain antibodies (pscFvs) that specifically target the NSP1β protein of PRRSV, which is essential for virus replication and immune evasion.
- These pscFvs are modified to act as cell-penetrating transbodies that can potentially inhibit PRRSV replication in infected cells, presenting a promising approach for treatment and prevention of the virus, although further research is needed to fully understand their antiviral mechanisms.
RNA-dependent RNA polymerase (RdRp) is a unique and highly conserved enzyme across all members of the RNA virus superfamilies. Besides, humans do not have a homolog of this protein. Therefore, the RdRp is an attractive target for a broadly effective therapeutic agent against RNA viruses.
View Article and Find Full Text PDFThis study aimed to determine the prevalence and intensity of intestinal helminth infections (IHIs) among rural villagers in Waeng Noi district, Khon Kaen Province, northeastern Thailand. A cross-sectional study was conducted between March 1 and July 30, 2018, among rural villagers from 30 rural villages in 2 subdistricts. The participants were selected from the village enrollment list after proportional allocation of the total sample size.
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