Publications by authors named "K Thorn"
Article Synopsis
- Herpes simplex virus type 2 (HSV-2) primarily causes genital herpes but can lead to meningitis in rare cases, prompting research using a murine model to understand its effects on the central nervous system (CNS).
- The study found that the Fas and FasL pathways are activated in the CNS during HSV-2 infection, and mice lacking these pathways exhibited worse disease outcomes and higher viral loads.
- Overall, the research suggests that the Fas/FasL pathway is crucial for controlling inflammation and facilitating proper immune responses in the spinal cord during HSV-2 infection.
Care home residents are vulnerable to severe outcomes from infections such as COVID-19 and influenza. However, measures to control outbreaks, such as care home closures to visitors and new admissions, have a detrimental impact on their quality of life. Many infections and outbreaks could be prevented but the first step is to measure them reliably.
View Article and Find Full Text PDFBackground: Guideline-directed heart failure therapy with angiotensin receptor blocker/neprilysin inhibitor (ARNi) and sodium-glucose transporter inhibitors (SGLT2i) has been incrementally beneficial in improving outcomes in heart failure patients.
Objective: Evaluate the feasibility and efficacy of guideline-directed medical therapy (GDMT) in adults congenital heart disease (ACHD) patients.
Methods: In a retrospective cohort study, ACHD patients with either New York Heart Association (NYHA) Class II symptoms or systemic ejection fraction (EF) <45%, optimized on a combination of beta-blocker (BB), ARNi, mineralocorticoid receptor antagonist (MRA) and SGLT2i were evaluated.
Inherited deficiency of the RNA lariat-debranching enzyme 1 (DBR1) is a rare etiology of brainstem viral encephalitis. The cellular basis of disease and the range of viral predisposition are unclear. We report inherited DBR1 deficiency in a 14-year-old boy who suffered from isolated SARS-CoV-2 brainstem encephalitis.
View Article and Find Full Text PDFObjective: The Memory Binding Test (MBT) shows promise in detecting early cognitive changes associated with Alzheimer's disease (AD). This study assesses the psychometric properties (i.e.
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