Publications by authors named "K Thapa"

Background: Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder usually diagnosed through polysomnography (PSG). Moderate to severe OSA can significantly increase morbidity and mortality. Existing screening tools have limited accuracy.

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  • Peutz-Jeghers syndrome (PJS) is a rare genetic disorder that causes gastrointestinal polyps and skin pigmentation, leading to complications like abdominal pain and intestinal obstruction from intussusception.
  • A case study details a 36-year-old woman with symptoms such as flank pain and melena, who was diagnosed with PJS after imaging and surgery revealed jejuno-jejunal intussusception and multiple polyps.
  • PJS stems from mutations in the STK11 gene, and regular screenings are vital for detecting cancer and monitoring polyp growth, with surgical intervention recommended for significant polyps and intussusception cases.
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Nematic liquid crystals exhibit nanosecond electro-optic response to an applied electric field which modifies the degree of orientational order without realigning the molecular orientation. However, this nanosecond electrically modified order parameter (NEMOP) effect requires high driving fields, on the order of 10 V/m for a modest birefringence change of 0.01.

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At the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer.

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  • By 2030, one in six people globally will be elderly, with a significant rise in the elderly population in Nepal, making healthcare accessibility a critical issue.
  • A mixed-method study in Parbat, Nepal, surveyed 355 individuals aged 60 and above for quantitative data and conducted in-depth interviews with 18 participants, analyzing their healthcare service utilization.
  • The results showed a 65.4% utilization rate, influenced by factors such as ethnicity, health status, transportation means, and challenges like long waiting times, insufficient medicine, and lack of trained staff, indicating that many elderly individuals still face barriers to accessing healthcare.
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