Publications by authors named "K Thanapirom"
Background: Clot waveform analysis (CWA) provides a global assessment of hemostasis and may be useful for patients with cirrhosis with complex hemostatic abnormalities. This study aimed to assess the association between prothrombin time (PT-) and activated partial thromboplastin time (aPTT-) based CWA parameters and cirrhosis severity and prospectively evaluate the role of CWA in predicting mortality and acute decompensation (AD) over 1 year.
Methods: This prospective study included adult patients with cirrhosis between June 2021 and December 2023 at Chulalongkorn University Hospital.
Background & Aims: Acute-on-chronic liver failure is a syndrome characterized by organ failure and high short-term mortality. The lack of reliable biomarkers for the early detection of acute-on-chronic liver failure is a significant challenge. Endothelial dysfunction plays a key role in the development of organ failure.
View Article and Find Full Text PDFBackground: The prevalence of hepatitis C virus (HCV) infection among Thai adults is 0.5%-1.0%.
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- Acute liver failure (ALF) in dengue patients is uncommon but highly fatal; identifying those at risk is crucial for improving survival rates.
- A study involving 2532 dengue patients revealed that factors like international normalized ratio, bilirubin, albumin, and creatinine can predict the likelihood of ALF and in-hospital mortality in patients with dengue-induced severe hepatitis (DISH).
- Several prognostic scores, including the MELD score and ALBI score, effectively predicted ALF and mortality, demonstrating high sensitivity and specificity in clinical assessments.
The correlation between circulating microbes and sepsis as well as proinflammatory diseases is increasingly gaining recognition. However, the detection of microbes' cell-free DNA (cfDNA), which exist at concentrations of a billion times lower than blood proteins, poses a significant challenge for early disease detection. Here, we present Nano mechanics combined with highly sensitive readout sequences to address the challenges of ultralow counts of disease biomarkers, thus enabling robust quantitative monitoring of chronic medical conditions at different stages of human disease progression.
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