Publications by authors named "K Teich"
Patients with acute myeloid leukemia (AML) who experience relapse following allogeneic hematopoietic cell transplantation (alloHCT) face unfavorable outcomes regardless of the chosen relapse treatment. Early detection of relapse at the molecular level by measurable residual disease (MRD) assessment enables timely intervention, which may prevent hematological recurrence of the disease. It remains unclear whether molecular MRD assessment can detect MRD before impending relapse and, if so, how long in advance.
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- Mycoplasma hyosynoviae is a bacteria found in the upper respiratory tract of pigs that can cause arthritis; however, there's limited understanding of its spread due to poor typing methods.
- This study developed two typing methods: a conventional multi locus sequence typing (MLST) and a core genome MLST (cgMLST) based on genome sequences from various pig strains.
- The findings showed that while both methods produced similar results, cgMLST provided more detailed differentiation of closely related strains, making it more suitable for epidemiological studies despite MLST being quicker and cheaper.
Donor lymphocyte infusions (DLIs) can directly target leukemic cells through a graft-versus-leukemia effect and play a key role in the prevention and management of relapse after allogeneic hematopoietic cell transplantation (alloHCT). Predictors of response to DLIs are not well established. We evaluated measurable residual disease (MRD) before, 30 and 90 days after DLI treatment as biomarkers of response.
View Article and Find Full Text PDFThe nutritional benefits of rye (and therefore rye bran) are mainly due to its high content of fermentable dietary fiber, the non-starch polysaccharides (NSP). Microorganisms in the large intestine are able to convert these into short-chain fatty acids (SCFA), including butyrate. Butyrate strengthens the epithelial barrier function in the colon by nourishing the enterocytes and inhibiting the spread of in the intestinal tract.
View Article and Find Full Text PDFRelapse in patients with acute myeloid leukemia (AML) is common and is associated with a dismal prognosis. Treatment options are limited and the understanding of molecular response patterns is still challenging. We analyzed the clonal response patterns of 15 patients with relapsed/refractory AML treated with selinexor in a phase II trial (SAIL).
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