Investigations on the mutagenicity of 1,4-dichlorobenzene and its main metabolite 2,5-dichlorophenol in vivo and in vitro.

The genotoxic potential of 1,4-dichlorobenzene (1,4-DCB) has been extensively evaluated in vitro and in vivo. The majority of the studies demonstrated the absence of a genotoxic potential for 1, 4-DCB. At variance are a bone marrow micronucleus test (MNT) after intraperitoneal (i.

In vitro mutagenicity studies on cyproterone acetate using female rat hepatocytes for metabolic activation and as indicator cells.

The synthetic sex steroid cyproterone acetate (CPA) was shown to induce DNA repair in primary hepatocytes from female rats, confirming previous reports about a sex-specific genotoxic potential of CPA in female rat liver. CPA did not induce gene mutations or chromosomal aberrations in V79 Chinese hamster cells co-cultivated with hepatocytes from female rats as the metabolizing system. Hepatocytes from the same rats under identical exposure conditions as in the positive unscheduled DNA synthesis (UDS) test were used in these experiments.