Publications by authors named "K Taylor Van Hoose"
Objective: To determine the association between initial delivery room (DR) ventilator (conventional mechanical ventilation [CMV] versus high frequency oscillatory ventilation [HFOV] and hospital outcomes for infants with severe congenital diaphragmatic hernia (CDH).
Study Design: Quasi-experimental design before/after introducing a clinical protocol promoting HFOV. The primary outcome was first blood gas parameters.
Introduction: Unlike white adipose tissue depots, bone marrow adipose tissue (BMAT) expands during caloric restriction (CR). Although mechanisms for BMAT expansion remain unclear, prior research suggested an intermediary role for increased circulating glucocorticoids.
Methods: In this study, we utilized a recently described mouse model () to exclusively target bone marrow adipocytes (BMAds) for elimination of the glucocorticoid receptor (GR) (i.
Update on Management and Outcomes of Congenital Diaphragmatic Hernia.
J Intensive Care Med
December 2024
Infants with congenital diaphragmatic hernia (CDH) benefit from comprehensive multidisciplinary teams that have experience in caring for the unique and complex issues associated with CDH. Despite prenatal referral to specialized high-volume centers, advanced ventilation strategies and pulmonary hypertension management, and extracorporeal membrane oxygenation, mortality and morbidity remain high. These infants have unique and complex issues that begin in fetal and infant life, but persist through adulthood.
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- Lipodystrophy syndromes involve the loss of adipose tissue and result from genetic or acquired causes, with LMNA-related cases classified by severity.
- The study analyzed 494 patients from the researchers' cases and published studies to identify clinical features and genotype-phenotype relationships.
- Findings highlighted common variants linked to metabolic issues, with early diabetes and dyslipidemia as notable concerns, emphasizing their connection to acute pancreatitis risks among affected individuals.
Respiratory function after birth in infants with congenital diaphragmatic hernia.
Arch Dis Child Fetal Neonatal Ed
September 2023
Objective: To characterise the transitional pulmonary physiology of infants with congenital diaphragmatic hernia (CDH) using measures of expiratory tidal volume (TV) and end-tidal carbon dioxide (ETCO).
Design: Prospective single-centre observational study.
Setting: Quaternary neonatal intensive care unit.