Publications by authors named "K Tascilar"
Background: CD19-targeting chimeric antigen receptor (CAR) T-cell therapy has shown remarkable outcomes in patients with systemic lupus erythematosus. The effects of CD19-targeting CAR T cells on organ manifestations in patients with systemic sclerosis have yet to be characterised. B cells have a central role in the pathogenesis of systemic sclerosis.
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- The study investigates the diagnostic accuracy of two digital tools, an AI-based symptom checker (Ada) and a web-based self-referral tool (Rheport), for identifying inflammatory rheumatic diseases (IRDs) among patients at three rheumatology centers.
- A total of 600 patients participated, with results showing that Rheport and Ada had varying levels of success in correctly identifying IRDs, achieving diagnostic accuracies of 52% and 58% respectively.
- The tools notably had better performance in diagnosing rheumatoid arthritis compared to other IRDs, with Ada showing a higher sensitivity for this specific condition.
The accruing evidence about the efficacy of anti-IL-1 agents in Familial Mediterranean Fever (FMF) patients led to their widespread off-label use. Therefore, identifying precise indications and clinical characteristics of IL-1i-warranting patients are important. This study investigated the clinical characteristics and treatment indications of patients with FMF requiring interleukin 1 inhibition therapy (IL-1i).
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- The study aimed to investigate molecular tissue changes at the entheses in patients with psoriasis (PsO), psoriatic arthritis (PsA), and healthy controls using advanced imaging techniques.
- Researchers conducted a cross-sectional study that included clinical assessments, ultrasound, and multispectral optoacoustic tomography (MSOT) to analyze changes in hemoglobin, oxygen saturation, collagen, and lipid levels across different groups.
- Results showed that both PsO and PsA patients had significant alterations in tissue composition, particularly in oxygenated hemoglobin and collagen levels, indicating a shared immunometabolic change linked to inflammation within these conditions.
Background: Autoinflammatory diseases (AIDs) are rare, mostly genetic diseases that affect the innate immune system and are associated with inflammatory symptoms. Both paediatric and adult patients face daily challenges related to their disease, diagnosis and subsequent treatment. For this reason, a survey was developed in collaboration between the FMF & AID Global Association and the Erlangen Center for Periodic Systemic Autoinflammatory Diseases.
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