Publications by authors named "K Tanita"
Background: Precise skin phenotypic data are indispensable in accurately diagnosing atopic dermatitis (AD). Therefore, this study examined the interobserver concordance for AD and non-AD diagnoses between two dermatologists. AD prevalence determined by the self-reported physician diagnoses and the diagnoses determined from the United Kingdom (UK) diagnostic criteria were compared with the diagnoses made by the two dermatologists, using data from a skin health survey.
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- - A new anticancer nanodrug has been created that is effective in fighting cancer with minimal side effects, avoiding the need for common additives or nanocarriers.
- - The nanodrug consists of nano-prodrugs made from homodimeric prodrugs of SN-38, which are stable but release the active drug specifically in cancer cells when a certain bond is broken by glutathione.
- - In tests, the nano-prodrugs showed far superior tumor-fighting capabilities compared to irinotecan, primarily due to better accumulation in tumors and a targeted drug release mechanism.
Article Synopsis
- Researchers designed nanoparticles that become active drugs when they dissolve inside cells, specifically targeting cancer cells using hydrogen peroxide.
- The study aims to clarify how these nanoparticles release their drugs when they interact with hydrogen peroxide in cancerous environments.
- It includes experiments that simulate cancer cell conditions to measure and understand the speed and efficiency of the drug release process.
Article Synopsis
- Identifying cells infected by Epstein-Barr virus (EBV) is crucial for understanding the disease's development, creating treatment plans, and predicting patient outcomes.
- The study utilized the PrimeFlow™ RNA Assay Kit to detect EBV-encoded small RNAs (EBERs) in various patient groups, including those with chronic active EBV disease and other EBV-related disorders.
- Findings revealed that patients with chronic active EBV disease showed widespread infection in T and NK cells, while other disorders demonstrated a mix of infected cell types, indicating that EBV may affect multiple cell types beyond just B cells.