Publications by authors named "K Tanese"
Localized lipoatrophy is a rare condition characterized by the localized loss of subcutaneous adipose tissue. It may occur idiopathically without specific triggers. The pathogenesis of idiopathic localized lipoatrophy remains largely unknown.
View Article and Find Full Text PDFSince nail psoriasis restricts the patient's daily activities, therapeutic intervention based on reliable and reproducible evaluation is critical. The Nail Psoriasis Severity Index (NAPSI) is a validated scoring tool, but its usefulness is limited by interobserver variability. This study aimed to develop a reliable and accurate NAPSI scoring tool using deep learning.
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- Atopic dermatitis (AD) is a chronic skin disease characterized by intense itching, and new treatments like dupilumab have been developed but predicting the right treatment for each patient is challenging.
- A study involving 110 AD patients aimed to identify factors and biomarkers that could indicate how well patients might respond to dupilumab, using various scales for assessment.
- Findings showed that higher baseline serum LDH levels and certain comorbidities, like food allergies, were linked to poorer treatment outcomes, suggesting these could help guide treatment decisions for AD patients.
Melanoma is an aggressive tumour with poor prognosis that arises from the malignant transformation of melanocytes. Over the past few decades, intense research into the pathogenesis of melanoma has led to the development of BRAF and immune checkpoint inhibitors, including antibodies against programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated protein 4 (CTLA-4), which have shown clinically significant efficacy. However, some tumours do not respond to these therapies initially or become treatment resistant.
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- - The study investigates the effectiveness of trastuzumab and docetaxel chemotherapy for treating metastatic extramammary Paget's disease (EMPD), a rare cancer that shows similarities to breast cancer, particularly regarding HER2 expression.
- - Thirteen Japanese patients participated in this phase II trial, receiving the chemotherapy combination for up to two years, with a primary focus on measuring response rates and safety.
- - Results showed a high objective response rate of 76.9% after three cycles of treatment, with manageable side effects, suggesting that this combination therapy is a promising option for HER2-positive metastatic EMPD.