Publications by authors named "K Tanakaya"
Aim: Lynch syndrome (LS) is a dominantly inherited syndrome characterized by an increased risk for LS associated tumors such as colorectal cancer (CRC) and gastric cancer (GC). However, the clinical benefit of surveillance for GC remains unclear while it has already been recommended for CRC. This study aimed to elucidate the clinical features of GC in Japanese individuals with LS, and the risk of developing multiple GCs to build regional-tailored surveillance programs in LS patients with GC.
View Article and Find Full Text PDFObjective Screening and surveillance methodologies for Lynch syndrome (LS) in Japan. This study assessed the changes in LS knowledge and practice trends. Methods In 2020 and 2022, 2 questionnaire surveys were administered to 3574 councilors of the Japanese Society of Gastroenterology to assess changes in LS-related knowledge and practices.
View Article and Find Full Text PDFArticle Synopsis
- Spontaneous hemoperitoneum is a rare but serious condition, and gastrointestinal stromal tumors (GIST) can be a difficult-to-diagnose cause of this condition due to its infrequency.
- A 76-year-old Japanese man experienced sudden abdominal pain and was eventually diagnosed with a high-risk extraluminal gastric GIST after imaging and exploratory surgery.
- This case underscores the importance of follow-up imaging like CT and FDG-PET/CT in identifying GIST and emphasizes the necessity for surgical intervention to investigate unexplained abdominal bleeding.
Background: Adult intussusception is a rare condition that is often associated with a high incidence of malignancy. The optimal management strategy remains controversial, particularly regarding the necessity for bowel reduction before resection. To date, there is a paucity of data on adult intussusception in the English literature.
View Article and Find Full Text PDFArticle Synopsis
- A new model for predicting germline pathogenic variants (GPVs) of the APC gene in patients with adenomatous polyposis is being developed to aid in clinical diagnosis and management, especially when genetic testing is unavailable.
- In a study of 162 patients, 55.6% were found to have GPVs of the APC gene, with key predictors identified, including age under 40, 100 or more polyps, fundic gland polyposis, and a family history of colorectal polyposis.
- The predictive model demonstrated high accuracy (area under the curve of 0.91) and aims to assist both patients and healthcare providers in deciding on the necessity of genetic testing.