Publications by authors named "K Takeyama"
Article Synopsis
- Chronic kidney disease (CKD) often goes unnoticed early on but can lead to serious cardiovascular and kidney complications, making early detection essential for better health outcomes.
- This study focused on developing a prediction model to identify Japanese individuals with mild CKD who are at risk for hospitalization due to ischemic heart disease (IHD) or cerebrovascular disease (CVD), using data from a large cohort.
- The findings indicate significant predictors like age, sex, and comorbidities, and the model showed a good predictive ability, providing a valuable tool for healthcare providers to stratify patients and implement timely interventions.
Article Synopsis
- * The study utilized latent class analysis (LCA) on a sample of 12,168 participants to identify five distinct clusters of health behaviors, determining that a five-class model provided the best fit.
- * The identified clusters included diverse patterns such as those with healthy lifestyles but hospital aversion and middle-aged individuals in need of lifestyle changes, highlighting the necessity of targeted public health strategies.
Article Synopsis
- The EXTRA study is the first research trial to explore predictive biomarkers for the effectiveness of afatinib in patients with specific mutations in nonsmall cell lung cancer (NSCLC) using various biological analyses.
- Conducted in Japan, the prospective study involved 103 untreated patients and measured metrics like progression-free survival (PFS) and overall survival (OS) while administering afatinib at an initial daily dose of 40 mg.
- Results showed that after a median follow-up of 35 months, the median PFS was 18.4 months, with a 3-year PFS rate of 23.3%, and a 3-year OS rate of 58.5%, indicating a positive response to afatinib in
To enhance bone regeneration, the use of bone morphogenetic protein (BMP)-2 is an attractive option. Unfortunately, the dose-dependent side effects prevent its widespread use. Therefore, a novel osteogenic agent using a different mechanism of action than BMP-2 is highly desirable.
View Article and Find Full Text PDFBackground: Primary ciliary dyskinesia (PCD) is diagnosed through multiple methods, including transmission electron microscopy (TEM), a high-speed video microscopy analysis (HSVA), immunofluorescence (IF), and genetic testing. A primary cell culture has been recommended to avoid the misdiagnosis of secondary ciliary dyskinesia derived from infection or inflammation and improve diagnostic accuracy. However, primary cells fail to differentiate into ciliated cells through repeated passages.
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