Myelin is required for rapid nerve signaling and is emerging as a key driver of CNS plasticity and disease. How myelin is built and remodeled remains a fundamental question of neurobiology. Central to myelination is the ability of oligodendrocytes to add vast amounts of new cell membrane, expanding their surface areas by many thousand-fold.
View Article and Find Full Text PDFBackground: Auto-induction is a convenient way to produce recombinant proteins without inducer addition using lac operon-controlled Escherichia coli expression systems. Auto-induction can occur unintentionally using a complex culture medium prepared by mixing culture substrates. The differences in culture substrates sometimes lead to variations in the induction level.
View Article and Find Full Text PDFThe most prominent effect of the weakest link theory, which is used to derive the Weibull statistics of ceramic strength, is the size effect. In this study, we analyze the size effect on ceramic strength using the finite element analysis (FEA) methodology previously proposed by the authors. In the FEA methodology, the data of the microstructure distribution (i.
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