Publications by authors named "K Takagaki"
Article Synopsis
- Futibatinib, a new FGFR inhibitor developed by Taiho Pharmaceutical, was approved in Japan in June 2023 for treating inoperable biliary tract cancer with specific genetic changes after prior chemotherapy.
- This drug works by irreversibly binding to the FGFR receptor, inhibiting cancer cell growth more effectively than earlier FGFR inhibitors.
- In clinical studies, futibatinib demonstrated a 41.7% overall response rate in patients with certain types of bile duct cancer, showing a good safety profile and the potential to treat more cancer types in the future.*
Subthreshold depression is a risk factor for depression among university students. Positive environmental reinforcement is a significant mediator of avoidance and depression in healthy university students. However, this relationship is understudied in those with subthreshold depression or depression.
View Article and Find Full Text PDFBackground: Hyposalivation is treated using oral cholinergic drugs; however, systemic side effects occasionally lead to discontinuation of treatment. We aimed to investigate the effects of transdermal pilocarpine on the salivary gland skin on saliva secretion and safety in rats.
Methods: Pilocarpine was administered to rats orally (0.
Article Synopsis
- Disseminated carcinomatosis of the bone marrow is a complex condition caused by prostate cancer metastasizing to the bone marrow, which is often difficult to diagnose through imaging techniques.
- A case study of a 75-year-old man showed that despite treatment and increasing PSA levels, the diagnosis was made using a C-choline PET/CT scan that revealed diffuse uptake in the bone marrow, while a bone scan showed little abnormality.
- The patient's condition was confirmed through a biopsy and, despite starting docetaxel therapy, his PSA levels continued to rise, leading to his death four months after diagnosis, highlighting the aggressive nature of this metastatic cancer.
Introduction: Depression is highly prevalent among university students. While behavioral activation has been shown to be an effective psychotherapy for depression, there is a lack of research regarding the behavioral activation mechanism. Furthermore, although self-compassion seems to be a factor in promoting behavioral activation, no studies have attempted to validate a behavioral activation model that includes positive self-compassion.
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