Publications by authors named "K TAKATO"
Since the 1980s, it has been known that the administration of ganglioside GM1 to cultured cells induced or enhanced neuronal differentiation. GM1 mechanism of action relies on its direct interaction and subsequent activation of the membrane tyrosine kinase receptor, TrkA, which naturally serves as NGF receptor. This process is mediated by the sole oligosaccharide portion of GM1, the pentasaccharide β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-3)]-β-Gal-(1-4)-β-Glc.
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- The study focused on the immune response in healthcare workers after receiving the Pfizer-BioNTech vaccine, specifically how antibody and T-cell responses change over time.
- It followed 608 participants for 6 months, revealing that both antibody and T-cell levels peaked at about 3 weeks post-vaccination and decreased thereafter.
- Additionally, there were six cases of breakthrough infections, mostly asymptomatic, indicating that while immunity decreases, some individuals may still contract the virus even after vaccination.
Article Synopsis
- Helicobacter pylori causes gastritis by promoting specific T cells during infection, but how the immune system detects it isn’t completely clear since the bacteria can evade TLR detection.
- Recent research reveals that metabolites from H. pylori, modified from host cholesterol, worsen gastritis by interacting with C-type lectin receptors.
- Mice lacking Mincle showed reduced T cell responses and gastritis, while a mutant strain of H. pylori unable to produce certain cholesterol derivatives had a lower capacity to induce inflammation.
The C-type lectin receptors (CLRs) form a family of pattern recognition receptors that recognize numerous pathogens, such as bacteria and fungi, and trigger innate immune responses. The extracellular carbohydrate-recognition domain (CRD) of CLRs forms a globular structure that can coordinate a Ca ion, allowing receptor interactions with sugar-containing ligands. Although well-conserved, the CRD fold can also display differences that directly affect the specificity of the receptors for their ligands.
View Article and Find Full Text PDFChemical syntheses of the bacterial diglucosyl diacylglycerols 1-heptadecanoyl-2-pentadecanoyl-3-O-[6-O-(β-d-glucopyranosyl)-β-d-glucopyranosyl]-sn-glycerol and 1-(cis-13-octadecenoyl)-2-palmitoyl-3-O-[2-O-(α-d-glucopyranosyl)-α-d-glucopyranosyl]-sn-glycerol are described. The syntheses feature the stereoselective construction of glycosidic linkages in glycosylation reaction by utilizing glycosyl donors with stereodirecting cyclic silyl protective groups. The 1,1,3,3-tetraisopropyldisiloxane-1,3-diyl (TIPDS) group was used for formation of the β-glycosidic linkage, while the di-tert-butylsilylene (DTBS) group was used for α-linkage formation.
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