Publications by authors named "K T Zaĭtsev"
We studied the effect of bone marrow cells (BMC) and nanosecond repetitively pulsed microwaves (RPMs, 10 GHz, pulse duration 100 nsec, pulse repetition rate 8 Hz, peak power flux density (pPFD) 140 W/cm) on the regeneration of thermally damaged skin in rats. The combined use of BMC and RPMs accelerates separation of an eschar with its complete rejection on day 14 of the experiment. Histological analysis demonstrated a statistically significant increase in the relative area of the granulation tissue and thickness of newly formed epidermis in the group with combined exposure.
View Article and Find Full Text PDFArticle Synopsis
- Copper(II)-nitroxide molecular magnets can switch spin states like spin-crossover, but understanding their properties remains difficult, especially for light-induced changes.
- This study investigates the photoswitching and relaxation of Cu(hfac)L complexes with pyridine-based ligands using electron paramagnetic resonance (EPR) methods.
- Results show long-lasting photoinduced spin states at low temperatures, but the effectiveness of switching is influenced by the size of the radical ligands, providing insights into the underlying mechanisms for these molecular magnets.
Atherosclerosis is driven by the expansion of cholesterol-loaded 'foamy' macrophages in the arterial intima. Factors regulating foamy macrophage differentiation and survival in plaque remain poorly understood. Here we show, using trajectory analysis of integrated single-cell RNA sequencing data and a genome-wide CRISPR screen, that triggering receptor expressed on myeloid cells 2 (Trem2) is associated with foamy macrophage specification.
View Article and Find Full Text PDFCardiac contractility modulation (CCM) is based on electrical stimulation of the heart without alteration of action potential and mechanical activation, the data on its fundamental molecular mechanisms are limited. Here we demonstrate clinical and physiological effect of 12 months CCM in 29 patients along with transcriptomic molecular data. Based on the CCM effect the patients were divided into two groups: responders ( = 13) and non-responders ( = 16).
View Article and Find Full Text PDFProfibrotic VEGFR3-Dependent Lymphatic Vessel Growth in Autoimmune Valvular Carditis.
Arterioscler Thromb Vasc Biol
April 2024
Background: Rheumatic heart disease is the major cause of valvular heart disease in developing nations. Endothelial cells (ECs) are considered crucial contributors to rheumatic heart disease, but greater insight into their roles in disease progression is needed.
Methods: We used a -driven EC lineage-tracing approach to identify and track ECs in the K/B.