Publications by authors named "K T Nouri-Aria"
Article Synopsis
- The study investigates the link between allergic inflammation and airway remodelling in seasonal allergic rhinitis (AR) using a new nasal allergen challenge model.
- Twelve patients with moderate-severe AR underwent two sets of challenges (diluent followed by grass pollen) while their nasal symptoms and cytokine levels were monitored, along with nasal biopsies to assess inflammation.
- Results showed significant increases in nasal tissue eosinophils and IL-5 levels after allergen exposure, but no notable changes in indicators of airway remodelling compared to healthy controls.
Changes in student physical health behaviour: an opportunity to turn the concept of a Healthy University into a reality.
Perspect Public Health
November 2018
Aims:: Previous studies have reported a high prevalence of unhealthy behaviours in the student population, which the Healthy University concept is now seeking to address, by taking a settings approach to health promotion. This study investigated how far students are already seeking to make changes to improve their health behaviour while in a university setting, to help inform the development of Healthy Universities.
Methods:: Data on student health behaviour change, health indicators and demographics were gathered from 550 students attending two London universities, via an online questionnaire released through the student union email system at one university and through iPads at a student centre at the other.
Background: Myeloid (m) and plasmacytoid (p) dendritic cells (DCs) regulate immune responses to allergens, whereas it remains unclear whether abnormal DC function characterizes patients with airway allergy and whether putative dysfunction exists only in target organs. To evaluate DC function from patients with allergic rhinitis (AR), we assessed nasal, cutaneous as well as blood DCs after in vivo and in vitro allergen challenge, respectively.
Methods: DCs were immunostained in nasal and skin tissues, and cytokine expression was assessed by dual immunofluorescence.
Background: Chronic rhinosinusitis with nasal polyps (NP) and allergic rhinitis (AR) is characterized by local Th2 inflammation and up-regulation of IgE; however, IgE in NP is 'polyclonal' and allergen specific, whereas IgE in AR is 'oligoclonal' and allergen specific. Germinal center (GC) reactions occur in AR, while only the formation of GC-like structures in NP is described. The aim of this study was to investigate the involvement of local IgE production, class switch recombination, and receptor revision in NP.
View Article and Find Full Text PDFBackground: T-bet and GATA-3 are transcriptional factors involved in Th1 and Th2 cell differentiation, although their concomitant roles at protein levels in target organs during human allergic disease have not been assessed.
Objectives: We investigated the expression of T-bet and GATA-3 in nasal and cutaneous models of Th2 (grass-pollen allergen) and a cutaneous model of Th1 (PPD) responses in man.
Methods: Nasal biopsies were obtained at 8 h and skin biopsies at 8 and 48 h after allergen and PPD challenges, respectively, from 10 allergic rhinitics and 6 non-atopic controls.